HIV Treatment Adherence, Drug Resistance, Virologic Failure: Evolving Concepts

This weekly compilation of articles appearing in recently released journals and newsletters includes:

• Articles funded by the Agency for Healthcare Research and Quality (AHRQ) or authored by AHRQ researchers.
• Articles mentioning or discussing AHRQ staff, activities, and publications/products.
• Articles related to AHRQ-funded Evidence-based Practice Centers.
• Articles related to the U.S. Preventive Services Task Force or Put Prevention into Practice program.
• Articles mentioning the National Healthcare Disparities Report and National Healthcare Quality Report.
• Other research using AHRQ data or products.

AHRQ-Funded/Authored Articles

Infectious Disorders - Drug Targets
Nachega JB, Marconi VC, van Zyl GU, et al. HIV treatment adherence, drug resistance, virologic failure: evolving concepts. Infect Disord Drug Targets 2011 Apr 1; 11(2):167-74. [Supported by grant U18 HS16946 (to last author, Gross R).] Select to access the abstract.

JAMA
Ritchie CS, Roth DL, Allman RM. Living with an aging parent: "It was a beautiful invitation". JAMA 2011 Aug 17; 306(7):746-53. [Supported in part by grant R18 HS17786-02 (to first author); see comments in article by Swartz (JAMA, 2011) cited in AHRQ-Related Articles below.] Select to access the abstract.

Journal of Women's Health
LeMasters T, Sambamoorthi U. A national study of out-of-pocket expenditures for mammography screening. J Womens Health 2011 Aug 17. [Epub ahead of print. Supported in part by Collaborative Health Outcomes Research of Therapies and Services (CoHORTS) grant 1 P20 HS15390-02 (to first and second authors); uses 2007-2008 Medical Expenditure Panel Survey (MEPS) data, citing MEPS landing page on the AHRQ Web site, MEPS-HC Panel Design and Data Collection Process, MEPS HC-121: 2008 Full Year Consolidated Data File, 2010, MEPS HC-113: 2007 Full Year Consolidated Data File, 2009, Health Care Expenses for Adults with Chronic Conditions, 2005, MEPS Statistical Brief 203, 2008, Overview of Methodology for Imputing Missing Expenditure Data in the Medical Expenditure Panel Survey, MEPS Methodology Report 19, 2007, and AHRQ working paper Examination of Skewed Health Expenditure Data from the Medical Expenditure Panel Survey (MEPS), 2004, all published on AHRQ's MEPS Web; cites USPSTF recommendations on screening for breast cancer and related USPSTF-sponsored update by Nelson et al. (both in Ann Intern Med, 2009) and previous USPSTF-sponsored evidence summary on breast cancer screening (Ann Intern Med, 2002).] Select to access the abstract.

Pediatrics
Johnson KB, Lee CK, Spooner SA, et al. Automated dose-rounding recommendations for pediatric medications. Pediatrics 2011 Aug; 128(2):e422-e428. [Supported by grant R18 HS17216; authors "thank the agency for their support and thoughtful comments throughout this project." Also refer to AHRQ-funded article by Abou-Setta et al. (Ann Intern Med, 2011) cited in Evidence-based Practice Centers-Related Articles.] Select to access the abstract.

AHRQ-Related Articles

American Journal of Epidemiology
Abrahamowicz M, Beauchamp ME, Ionescu-Ittu R, et al. Reducing the variance of the prescribing preference-based instrumental variable estimates of the treatment effect. Am J Epidemiol 2011 Aug 15; 174(4):494-502. [Cites AHRQ-funded articles by Brookhart, Rassen, and Schneeweiss (Pharmacoepidemiol Drug Saf, 2010) and Schneeweiss et al. (CMAJ, 2007).] Select to access the abstract.

American Journal of Hospice and Palliative Medicine
Carter GT, Flanagan AM, Earleywine M, et al. Cannabis in palliative medicine: improving care and reducing opioid-related morbidity. Am J Hosp Palliat Care 2011 Aug; 28(5):297-303. [Cites AHRQ-funded article by Solomon et al. (Arch Intern Med, 2010).] Select to access the abstract.

Rasmussen KG, Richardson JW. Electroconvulsive therapy in palliative care. Am J Hosp Palliat Care 2011 Aug; 28(5):375-7. [Cites AHRQ-funded article by Lorenz et al. (Ann Intern Med, 2008).] Select to access the abstract.

Annals of Internal Medicine
Vidán MT, Sánchez E, Gracia Y, et al. Causes and effects of surgical delay in patients with hip fracture: a cohort study. Ann Intern Med 2011 Aug 16; 155(4):226-33. [Cites AHRQ-funded articles by Orosz et al. (JAMA, 2004, and J Am Geriatr Soc, 2002); see comments in article by Hung and Morrison cited below in this section.] Select to access the abstract.

Housri N, Coombs M, Orandi BJ, et al. Ethics and the law: is there common ground on informed consent for disparities in hospital outcomes? Ann Intern Med 2011 Aug 16; 155(4):260-4. [Cites AHRQ's Inpatient Quality Indicators Overview, as cited on AHRQ's Quality Indicators Web site, as an example of the use of institutional volume as a quality indicator; mentions AHRQ recommendations that "hospital volume should be used as a quality indicator for surgeries with outcomes that are driven by institutional volume" and that surgeries for esophageal and pancreatic cancer are the two cancer surgeries "having the strongest and most consistent volume-outcome relationship"; cites AHRQ-funded articles by Finalyson, Goodney, and Birkmeyer (Arch Surg, 2003) and Birkmeyer et al. (N Engl J Med, 2002, and Health Aff, 2002).] Select to access the abstract.

Hung WW, Morrison RS. Hip fracture: a complex illness among complex patients. Ann Intern Med 2011 Aug 16; 155(4):267-8. [Comments on article by Vidán et al. cited above in this section; cites AHRQ publication, Advances in Patient Safety: From Research to Implementation, Volume 1, Research Findings, 2005; cites AHRQ-funded articles by McLaughlin et al. (J Gen Intern Med, 2006), Siu et al. (Med Care, 2006), Orosz et al. (JAMA, 2004), and others.]

Peterson PN, Rumsfeld JS. The evolving story of guidelines and health care: does being NICE help? Ann Intern Med 2011 Aug 16; 155(4):269-71. [Cites AHRQ-funded article by Ho et al. (Circ Cardiovasc Qual Outcomes, 2010).]

Hernandez AF. Review: cardiac resynchronization reduces mortality and hospitalizations in patients with either more or less symptomatic HF. Ann Intern Med 2011 Aug 16; 155(4):JC207. [Cites AHRQ-funded article by Piccini et al. (Circulation, 2008).]

CMAJ
Boorsma M, Frijters DH, Knol DL, et al. Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: a cluster randomized trial. CMAJ 2011 Aug 9; 183(11):E724-E732. [Cites AHRQ-authored article by Spector, Cohen, and Pesis-Katz (Gerontologist, 2004).] Select to access the abstract.

Gerontologist
Berkman BJ. Seizing interdisciplinary opportunities in the changing landscape of health and aging: a social work perspective. Gerontologist 2011 Aug; 51(4):433-40. [Cites AHRQ-funded article by Trivedi et al. (N Engl J Med, 2005).] Select to access the abstract.

Troyer JL, Sause WL. Complaints against nursing homes: comparing two sources of complaint information and predictors of complaints. Gerontologist 2011 Aug; 51(4):516-29. [Cites AHRQ-funded articles by Castle and Ferguson (Gerontologist, 2010), Stevenson (Med Care, 2005), and Grabowski (J Gerontol Soc Sci, 2001).] Select to access the abstract.

International Journal for Quality in Health Care
Wong EL, Leung MC, Cheung AW, et al. A population-based survey using PPE-15: relationship of care aspects to patient satisfaction in Hong Kong. Int J Qual Health Care 2011 Aug; 23(4):390-6. [Cites AHRQ-funded articles by Needleman et al. (N Engl J Med, 2002) and Rydman et al. (Acad Emerg Med, 1999); cites article by Ng et al. (Emerg Med J, 2009) which uses AHRQ's Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey.] Select to access the abstract.

Wung CH, Yu TH, Shih CL, et al. Is it enough to set national patient safety goals? An empirical evaluation in Taiwan. Int J Qual Health Care 2011 Aug; 23(4):420-8. [Mentions AHRQ's development of patient safety indicators; cites AHRQ-funded articles by Pronovost, Miller, and Wachter (JAMA, 2006) and Longo et al. (JAMA, 2005); cites articles by Romano et al. (Health Serv Res, 2009) and Kristensen, Mainz, and Bartels (Int J Qual Health Care, 2009), both of which use AHRQ's patient safety indicators.] Select to access the abstract.

Chiang HY, Hsiao YC, Lin SY, et al. Incident reporting culture: scale development with validation and reliability and assessment of hospital nurses in Taiwan. Int J Qual Health Care 2011 Aug; 23(4):429-36. [Cites AHRQ-funded article by Gershon et al. (J Nurs Adm, 2004).] Select to access the abstract.

JAMA
Krumholz HM. Real-world imperative of outcomes research. JAMA 2011 Aug 17; 306(7):754-5. [Acknowledges editorial assistance from AHRQ Director Carolyn M. Clancy.]

Swartz K. Sharing the financial responsibility of caring for parents. JAMA 2011 Aug 17; 306(7):760-1. [Comments on AHRQ-funded article by Ritchie, Roth, and Allman (JAMA, 2011) cited in AHRQ-Funded/Authored Articles above.]

Lancet
Anker SD, Koehler F, Abraham WT. Telemedicine and remote management of patients with heart failure. Lancet 2011 Aug 20; 378(9792):731-9. [Cites AHRQ publication, Using Administrative Data to Monitor Access, Identify Disparities, and Assess Performance of the Safety Net, Appendix B. Ambulatory Care Sensitive Conditions, as published on AHRQ's Archive Web site.] Select to access the abstract.

Medical Care Research and Review
Lehnert T, Heider D, Leicht H, et al. Review: health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev 2011 Aug; 68(4):387-420. [Mentions the use of 2006 MEPS data in the Robert Wood Johnson Foundation report, Chronic Conditions: Making the Case for Ongoing Care, 2010, and 2005 MEPS data in article by Paez et al. (Health Aff, 2009); mentions AHRQ's involvement in the HHS Strategic Framework on Multiple Chronic Conditions initiative and its previous co-sponsorship of "two meetings in response to the changing care demands of elders with MCCs in the United States", which led to the development of a research agenda which is summarized and further explored in AHRQ-funded article by Norris et al. (J Am Geriatr Soc, 2008); cites AHRQ-authored article by Zhan, Sangl, Bierman, Miller, Friedman, Wickizer, and Meyer (authors are current and former AHRQ researchers) (JAMA, 2001), which uses MEPS data; cites AHRQ-funded articles by Qato et al. (JAMA, 2008), Norris et al. (N Engl J Med, 2003), and Gandhi et al. (N Engl J Med, 2003).] Select to access the abstract.

Alexander JA, Hearld LR, Hasnain-Wynia R, et al. Consumer trust in sources of physician quality information. Med Care Res Rev 2011 Aug; 68(4):421-40. [Mentions AHRQ as a source of public reports on comparative quality information.] Select to access the abstract.

Hall MA. Access to care provided by better safety net systems for the uninsured: measuring and conceptualizing adequacy. Med Care Res Rev 2011 Aug; 68(4):441-61. [Cites AHRQ publication, Tools for Monitoring the Health Care Safety Net, 2003, as published on the AHRQ Web site; cites AHRQ-funded articles by Blewett, Ziegenfuss, and Davern (Milbank Q, 2008) and Gresenz, Rogowski, and Escarce (Health Serv Res, 2007).] Select to access the abstract.

New England Journal of Medicine
Avidan MS, Jacobsohn E, Glick D, et al. Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med 2011 Aug 18; 365(7):591-600. [Cites AHRQ-funded article by Pronovost et al. (N Engl J Med, 2006).] Select to access the abstract.

Jena AB, Seabury S, Lakdawalla D, et al. Malpractice risk according to physician specialty. N Engl J Med 2011 Aug 18; 365(7):629-36. [Cites AHRQ-funded article by Studdert et al. (N Engl J Med, 2006).] Select to access the abstract.

Mangalmurti SS, Murtagh L, Mello MM. Medical malpractice in the military. N Engl J Med 2011 Aug 18; 365(7):664-70. [Cites AHRQ-funded articles by Studdert et al. (N Engl J Med, 2006) and Gallagher et al. (Arch Intern Med, 2006).]

Pediatrics
Schlapbach LJ, Aebischer M, Adams M, et al. Impact of sepsis on neurodevelopmental outcome in a Swiss national cohort of extremely premature infants. Pediatrics 2011 Aug; 128(2):e348-e357. [Cites AHRQ-funded article by Jeffries et al. (Infect Control Hosp Epidemiol, 2009).] Select to access the abstract.

Tham E, Calmes HM, Poppy A, et al. Sustaining and spreading the reduction of adverse drug events in a multicenter collaborative. Pediatrics 2011 Aug; 128(2):e438-e445. [Cites AHRQ-funded articles by Sharek et al. (Pediatrics, 2008), Kaushal et al. (JAMA, 2001), and Bates et al. (JAMA, 1997).] Select to access the abstract.

Weiner DL, Manzi SF, Briggs SM, et al. Response to challenges and lessons learned from hurricanes Katrina and Rita: a national perspective. Pediatrics 2011 Aug; 128 Suppl 1:S31-S33. [Cites AHRQ publication, Pediatric Terrorism and Disaster Preparedness: A Resource for Pediatricians, 2006, prepared by the American Academy of Pediatrics, and AHRQ/National Commission on Children and Disasters-sponsored report, 2010 Report to the President and Congress, 2010, both available on AHRQ's Archive Web site.]

Krug SE, Tait VF, Aird L. Helping the helpers to help children: advances by the American Academy of Pediatrics. Pediatrics 2011 Aug; 128 Suppl 1:S37-S39. [Cites AHRQ/National Commission on Children and Disasters-sponsored report, 2010 Report to the President and Congress, 2010, available on AHRQ's Archive Web site.]

U.S. Preventive Services Task Force (USPSTF)/Put Prevention Into Practice (PPIP)-Related Articles

American Journal of Epidemiology
Zhang X, Smith-Warner SA, Chan AT, et al. Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionals. Am J Epidemiol 2011 Aug 15; 174(4):459-67. [Cites USPSTF recommendations on routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer and related systematic review by Dubé et al. (both in Ann Intern Med, 2007).] Select to access the abstract.

Annals of Internal Medicine
Moyer VA, U.S. Preventive Services Task Force. Screening for bladder cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2011 Aug 16; 155(4):246-51. [Updates the 2004 USPSTF recommendation statement, Screening for Bladder Cancer; cites USPSTF-sponsored evidence synthesis Screening Adults for Bladder Cancer: Update of the 2004 Evidence Review for the U.S. Preventive Services Task Force, 2010, prepared by the Oregon Evidence-based Practice Center (EPC) under contract HHSA-290-2007-10057-I-EPC3 task order 3; cites USPSTF brief evidence update Screening for Bladder Cancer, 2004, and USPSTF-sponsored evidence review on screening adults for bladder cancer (Ann Intern Med, 2010).] Select to access the abstract.

Pfister AK, Welch CW, Emmett M. Screening for osteoporosis: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2011 Aug 16; 155(4):275-6. [Comments on USPSTF recommendations on screening for osteoporosis (Ann Intern Med, 2011); see additional comments by Nordin and author reply by Moyer, LeFevre, and Siu cited below in this section.]

Nordin C. Screening for osteoporosis: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2011 Aug 16; 155(4):276. [Comments on USPSTF recommendations on screening for osteoporosis (Ann Intern Med, 2011); see author reply by Moyer, LeFevre, and Siu cited below in this section.]

Moyer VA, LeFevre ML, Siu AL. Screening for osteoporosis: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2011 Aug 16; 155(4):276-7. [Authors are members of the USPSTF; responds to above comments on USPSTF recommendations on screening for osteoporosis (Ann Intern Med, 2011).]

Summaries for Patients. Screening for bladder cancer: recommendations from the U.S. Preventive Services Task Force. Ann Intern Med 2011 Aug 16; 155(4):I-36. [Summarizes USPSTF recommendations on screening for bladder cancer by Moyer and USPSTF cited above in this section.]

JAMA
Brown RS. Has the time come to include urine dipstick testing in screening asymptomatic young adults? JAMA 2011 Aug 17; 306(7):764-5. [Mentions that the USPSTF "has no current recommendation for CKD [chronic kidney disease], but the topic is under consideration", citing Topics in Progress, 2011, as published on the USPSTF Web site.]

Medscape
Lianov LS. Prescribing lifestyle medicine. 2011 Aug 15; Online. [Cites USPSTF recommendation statements Behavioral Counseling in Primary Care to Promote a Healthy Diet, 2011, Screening and Behavioral Counseling Interventions in Primary Care to Reduce Alcohol Misuse, 2004, and Counseling to Prevent Tobacco Use and Tobacco-Caused Disease, 2003, all published on the USPSTF Web site; cites USPSTF-sponsored article by Whitlock et al. (Am J Prev Med, 2002) on USPSTF methodologies; cites AHRQ-authored article by Lewis, Clancy (AHRQ director) et al. (Ann Intern Med, 1991).]

Pediatrics
Jasik CB, Adams SH, Irwin CE Jr, et al. The association of BMI status with adolescent preventive screening. Pediatrics 2011 Aug; 128(2):e317-e323. [Cites USPSTF recommendations on screening for obesity in children and adolescents (Pediatrics, 2010).] Select to access the abstract.

Journal of Corporation Law
Orentlicher D. Controlling health care costs through public, transparent processes: the conflict between the morally right and the socially feasible. J Corp Law 2011 Summer; 36(4):807-21. [Discusses and comments on 2009 USPSTF breast cancer screening recommendations, citing U.S. Preventive Services Task Force (USPSTF), as published on the AHRQ Web site; cites AHRQ-authored article by Zhan and Miller (current researcher in AHRQ's Center for Evidence and Outcomes and former AHRQ researcher, respectively.]

Medical Care Research and Review
Mojtabai R. Does depression screening have an effect on the diagnosis and treatment of mood disorders in general medical settings? An instrumental variable analysis of the National Ambulatory Medical Care Survey. Med Care Res Rev 2011 Aug; 68(4):462-89. [Cites USPSTF recommendations on screening for depression in adults (Ann Intern Med, 2009); cites USPSTF-sponsored systematic evidence review on screening for child and adolescent depression in primary care settings (Pediatrics, 2009) and evidence summary on screening for depression in adults (Ann Intern Med, 2002). Also refer to AHRQ-funded article by LeMasters and Sambamoorthi (J Womens Health, 2011), cited in AHRQ-Funded/Authored Articles.] Select to access the abstract.

Evidence-based Practice Centers-Related Articles

Annals of Internal Medicine
Abou-Setta AM, Beaupre LA, Rashiq S, et al. Comparative effectiveness of pain management interventions for hip fracture: a systematic review. Ann Intern Med 2011 Aug 16; 155(4):234-45. [Supported by contract HHSA 290-2007-10021; summarizes methodologies used in and findings from AHRQ research protocol document Comparative Effectiveness of Pain Management Interventions for Hip Fracture, 2009, prepared by the University of Alberta EPC under contract 290-02-0023; uses methodological approaches outlined in the AHRQ Methods Guide for Effectiveness and Comparative Effectiveness Reviews; originally published in Articles of Interest, 5/16/11 - 5/20/11.] Select to access the abstract.

Halim SA, Newby LK. Review: angiotensin-receptor blockers do not increase adverse cardiovascular outcomes. Ann Intern Med 2011 Aug 16; 155(4):JC2-2. [Cites AHRQ-funded systematic review by Matchar et al. (Ann Intern Med, 2008) on comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension, performed by the Duke EPC under contract 290-02-0025.]

Domecq JP, Prutsky G, Montori VM. Review: oral drugs for type 2 diabetes, alone or in combination, have different relative benefits and harms for surrogate endpoints. Ann Intern Med 2011 Aug 16; 155(4): JC2-4. [Summarizes and comments on AHRQ-funded updated comparative effectiveness review by Bennett et al. (Ann Intern Med, 2011) on comparative effectiveness and safety of medications for type 2 diabetes, prepared by the John Hopkins University EPC under contract 290-02-0018.]

International Journal for Quality in Health Care
Aiken LH, Sloane DM, Clarke S, et al. Importance of work environments on hospital outcomes in nine countries. Int J Qual Health Care 2011 Aug; 23(4):357-64. [Cites AHRQ-funded systematic review and meta-analysis by Kane et al. (Med Care, 2007) on the association of registered nurse staffing levels and patient outcomes, performed by the Minnesota EPC under contract 290-02-0009; cites AHRQ-funded articles by Aiken et al. (Med Care, 1999 and 1997).] Select to access the abstract.

James CD, Hanson K, Solon O, et al. Do doctors under-provide, over-provide or do both? Exploring the quality of medical treatment in the Philippines. Int J Qual Health Care 2011 Aug; 23(4):445-55. [Cites AHRQ-funded systematic review by Hussey et al. (Health Serv Res, 2009) on health care efficiency measures, performed by the Southern California EPC-RAND Corporation under contract 282-00-0005-21; cites AHRQ-authored article by Mutter, Rosko, and Wong (first and last authors are researchers in AHRQ's Center for Delivery, Organization, and Markets) (Health Serv Res, 2008). Also refer to article by Moyer and USPSTF (Ann Intern Med, 2011) cited in U.S. Preventive Services Task Force (USPSTF)/Put Prevention Into Practice (PPIP)-Related Articles.] Select to access the abstract.

Research by Others Using AHRQ Data or Products

Medical Care Research and Review
Carey K, Stefos T, Zhao S, et al. Excess costs attributable to postoperative complications. Med Care Res Rev 2011 Aug; 68(4):490-503. [Uses AHRQ's Elixhauser comorbidity index (Elixhauser et al., Med Care, 1998); cites AHRQ publication, Advances in Patient Safety: From Research to Implementation, Vol. 1: Research Findings, 2005; cites AHRQ-authored articles by Lipscomb, Yabroff, Brown, Lawrence et al. (Med Care, 2009), Encinosa and Hellinger (Health Serv Res, 2008), Rivard, Luther, Christiansen, Zhao, Loveland, Elixhauser et al. (Med Care Res Rev, 2008), Zhan, Friedman et al. (Health Aff, 2006), and Zhan and Miller (JAMA, 2003), all of which use AHRQ's Patient Safety Indicators, and Houchens, Elixhauser, and Romano (Jt Comm J Qual Patient Saf, 2008), which uses AHRQ's Present-on-Admission Indicators; cites article by Romano et al. (Health Serv Res, 2009), which uses AHRQ's Patient Safety Indicators, and AHRQ-funded articles by Basu and Manning (Med Care, 2009), Classen et al. (Qual Saf Health Care, 2005), and Bates et al. (JAMA, 1997 and 1995).] Select to access the abstract.

Pediatrics
Tieder JS, Hall M, Auger KA, et al. Accuracy of administrative billing codes to detect urinary tract infection hospitalizations. Pediatrics 2011 Aug; 128(2):323-30. [Uses AHRQ's Pediatric Quality Indicators "18" definition to determine applicable ICD-9 codes for urinary tract infection; mentions AHRQ's programs to develop "meaningful, reliable, and actionable metrics", citing AHRQ-funded article by McDonald et al. (Pediatrics, 2009) and article by Conway (former AHRQ researcher) and Keren (J Pediatr, 2009), both of which use AHRQ's Pediatric Quality Indicators; cites AHRQ publication, Care of Children and Adolescents in US Hospitals, HCUP Fact Book 4, 2003, and Pediatric Quality Indicators Overview, as published on AHRQ's Quality Indicators Web site. lso refer to AHRQ-funded article by LeMasters and Sambamoorthi (J Womens Health, 2011) cited in AHRQ-Funded/Authored Articles.] Select to access the abstract.