123. Treatment Recommendations: Medications (Continued)
Treating Tobacco Use and Dependence: 2008 Update
Text version of slide presentation.
Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months post-quit (n = 86 studies) (Continued)
Medication | Number of arms | Estimated odds ratio (95% C.I.) |
Estimated abstinence rate (95% C.I.) |
---|---|---|---|
Placebo | 80 | 1.0 | 13.8 |
Combination therapies | |||
Patch (long-term; > 14 weeks) + ad lib NRT (gum or spray) | 3 | 3.6 (2.5, 5.2) | 36.5 (28.6, 45.3) |
Patch + Bupropion SR | 3 | 2.5 (1.9, 3.4) | 28.9 (23.5, 35.1) |
Patch + Nortriptyline | 2 | 2.3 (1.3, 4.2) | 27.3 (17.2, 40.4) |
Patch + Inhaler | 2 | 2.2 (1.3, 3.6) | 25.8 (17.4, 36.5) |
Patch + Second generation antidepressants (paroxetine, venlafaxine) | 3 | 2.0 (1.2, 3.4) | 24.3 (16.1, 35.0) |
Medications not shown to be effective | |||
Selective Serotonin Reuptake Inhibitors (SSRIs) | 3 | 1.0 (0.7, 1.4) | 13.7 (10.2, 18.0) |
Naltrexone | 2 | 0.5 (0.2, 1.2) | 7.3 (3.1, 16.2) |